European Eye Research

Quantitative assessment of the parafoveal vessel density and ganglion cell inner plexiform layer thickness in non-proliferative macular telangiectasia type 2 [Eur Eye Res]
Eur Eye Res. 2024; 4(3): 209-216 | DOI: 10.14744/eer.2024.95530  

Quantitative assessment of the parafoveal vessel density and ganglion cell inner plexiform layer thickness in non-proliferative macular telangiectasia type 2

Aylin Karalezli1, Cansu Kaya1, Sema Kaderli2, Ahmet Kaderli1, Sabahattin Sul1
1Department of Ophthalmology, Mugla Sitki Kocman University, Mugla, Türkiye
2Department of Ophthalmology, Mugla Training and Research Hospital, Mugla, Türkiye

PURPOSE: The study aimed to evaluate the vessel densities (VDs) and ganglion cell inner plexiform layer (GCIPL) thicknesses in macular telangiectasia (MacTel) Type 2.

METHODS: Thirty-six eyes with MacTel Type 2 and 30 controls were included in this prospective study. Based on the presence of ellipsoid zone (EZ) disruption two groups were formed: Group 1, MacTel eyes with intact EZ. Group 2; with EZ disruption.
RESULTS: In all MacTel eyes, a decrease was obtained in VDs and temporal parafoveal thickness in 1st year. (For group 1 p=0.006, p=0.045. For group 2 p=0.002, p=0.02) The average and minimum GCIPL also decreased in Group 2. (For average p=0.005, for minimum p=0.003) The mean VD, temporal and nasal thicknesses, average minimum GCIPL, and retinal nerve fiber layer were lower in Group 2 in the final visit.

CONCLUSION: VDs and GCIPL thickness may be useful parameters in the follow-up of MacTel Type 2 disease in which microvascular changes are observed in parallel with neurodegeneration.

Keywords: Ganglion cell inner plexiform layer thickness, nonproliferative macular telangiectasia, parafoveal vessel density


Aylin Karalezli, Cansu Kaya, Sema Kaderli, Ahmet Kaderli, Sabahattin Sul. Quantitative assessment of the parafoveal vessel density and ganglion cell inner plexiform layer thickness in non-proliferative macular telangiectasia type 2. Eur Eye Res. 2024; 4(3): 209-216

Corresponding Author: Sema Kaderli, Türkiye


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