Evaluation of Laboratory Findings in the Treatment of Acute Ischemic Stroke

INTRODUCTION: Aim: Acute ischemic stroke is an emergency clinical condition resulting from occlusion of intracranial artery leading to neural tissue destruction. In this study, we aimed to evaluate whether lactate levels and monocyte/high-density lipoprotein (HDL) ratio can be used as a marker in predicting treatment outcomes in patients who underwent intravenous thrombolysis (IVT) or mechanical thrombectomy (MT) after IVT.
METHODS: In this retrospective study, demographic data, clinical status, radiological results, laboratory data, the National Institutes of Health Stroke Scale (NIHSS) scores on admission and after treatment, and clinical data of patients who were diagnosed with acute ischemic stroke and underwent IVT or IVT+MT between January 01, 2019 and December 31, 2019 in the Emergency Medicine Clinic of Şişli Hamidiye Etfal Training and Research Hospital were evaluated. The vessels of the patients causing ischemic pathology were evaluated and divided into three groups as middle cerebral artery (MCA), posterior cerebral artery (PCA) and anterior cerebral artery (ACA). The distribution of quantitative data was evaluated with the Kolmogorov-Smirnov test. The Kruskal-Wallis, Mann-Whitney U test was used to compare independent quantitative data between groups.
RESULTS: Results: A total of 189 cases, 57.7% of whom were male, with a mean age of 69.5 ± 12.9, were included in our study. The patients were divided into three groups according to the occluded arteries as MCA, PCA and ACA. Monocytes/HDL and lactate levels were similar among groups. Total cholesterol/HDL ratio was found to be significantly higher in the PCA group compared to MCA group (p< 0.05). There was a significant decrease in the NIHSS scores of the patients after treatment compared to the scores at admission (p< 0.05).
DISCUSSION AND CONCLUSION: Conclusion: It was shown that monocyte/HDL ratio and lactate levels were not significant in predicting the success of treatment and neurological improvement in patients with acute ischemic stroke.