İstanbul Medical Journal

Benign Meme Bozukluklarının Hipotiroidizmle İlişkisi [İstanbul Med J]
İstanbul Med J. 2018; 19(3): 0-0

Benign Meme Bozukluklarının Hipotiroidizmle İlişkisi

Nooshin Shirzad1, Sadaf Alipour2, Azin Saberi1, Akram Seifollahi3, Hadith Rastad4, Ladan Hosseini4
1Department Of Surgery, Arash Women’s Hospital, Tehran University Of Medical Sciences, Tehran, Iran
2Endocrinology And Metabolism Research Center, Endocrinology And Metabolism Clinical Sciences Institute, Endocrinology And Metabolism Research Institute, Tehran University Of Medical Sciences, Tehran, Iran
3Department Of Pathology, Arash Women’s Hospital, Tehran University Of Medical Sciences, Tehran, Iran
4Research Development Center, Arash Women’s Hospital, Tehran University Of Medical Sciences, Tehran, Iran

GİRİŞ ve AMAÇ: Meme semptomlarından şikayet eden kadınların yarısından çoğu benign meme hastalıklarından etkilenmektedir. Tiroid fonksiyon bozukluğu etyoloji olarak ilişkilendirilmiştir; Bu nedenle benign meme hastalıklarının (BBD) hipotiroidi ile ilişkisini değerlendirmek için bir çalışma yaptık.
YÖNTEM ve GEREÇLER: Kesitsel tipteki bu çalışmada, tiroid bozukluğu öyküsü olmayan BBD'li 226 kadın, ardışık olarak vaka grubu olarak çalışmaya alındı. Kontroller arasında 206 sağlıklı kadın vardı. Tüm katılımcılardan kan örnekleri alındı ve her örnekte serbest tiroksin, tri-iyodotironin, tiroid uyarıcı hormon, prolaktin ve anti-tiroid peroksidaz antikoru düzeyleri ölçüldü.
BULGULAR: Hipotiroidi kontrol grubunda (%5.3) de mastalji ile karşılaştırıldığında fibrokistik changes (%7.9) durumlarda olduğu gibi (%2.6) alt grupları (%1.4) ve meme deşarj daha önemli ölçüde olmayan durumda (% 5.8) daha sık sık (p değeri = 0.85 ve 0.09, sırasıyla). Tersine, Hashimoto hastalığı denetimlerde biraz daha sık, ama fark önemli değildi (p değeri = 0.70).
TARTIŞMA ve SONUÇ: : Bu çalışmada, hipotiroidi ve benign meme hastalıkları arasında anlamlı bir ilişki bulunmadığı gösterilmiştir.

Anahtar Kelimeler: Meme, Benign, Tiroid, Hashimoto, Otoimmünite


Association of Benign Breast Disorders with Hypothyroidism

Nooshin Shirzad1, Sadaf Alipour2, Azin Saberi1, Akram Seifollahi3, Hadith Rastad4, Ladan Hosseini4
1Department Of Surgery, Arash Women’s Hospital, Tehran University Of Medical Sciences, Tehran, Iran
2Endocrinology And Metabolism Research Center, Endocrinology And Metabolism Clinical Sciences Institute, Endocrinology And Metabolism Research Institute, Tehran University Of Medical Sciences, Tehran, Iran
3Department Of Pathology, Arash Women’s Hospital, Tehran University Of Medical Sciences, Tehran, Iran
4Research Development Center, Arash Women’s Hospital, Tehran University Of Medical Sciences, Tehran, Iran

INTRODUCTION: More than half of women complaining of breast symptoms are affected by benign breast disorders. Thyroid dysfunction has been implicated as the etiology; we therefore conducted a study to assess association between benign breast disorders (BBD) and hypothyroidism.
METHODS: In this case-control study, 226 women with BBD without history of thyroid disorders consecutively were recruited as case group. Controls included 206 healthy women without breast disease. Blood samples were taken and levels of free thyroxin (FT4), tri-iodothyronine (T3), thyroid stimulating hormone (TSH), prolactin and anti-thyroid peroxidase antibody (TPO Ab) were measured.
RESULTS: Hypothyroidism was non-significantly more frequent in the case (5.8%) than in the control group (5.3%) as well as in cases of fibrocystic changes (7.9%) in comparison with mastalgia (1.4%) and nipple discharge (2.6%) in BBD subgroups (p= 0.85 and 0.09, respectively). In contrary, Hashimoto disease was slightly more frequent in controls, but the difference was not significant (p = 0.70).
DISCUSSION AND CONCLUSION: The present study demonstrates no significant association between hypothyroidism and benign breast disorders.

Keywords: Breast, Benign, Thyroid, Hashimoto, Autoimmunity


Nooshin Shirzad, Sadaf Alipour, Azin Saberi, Akram Seifollahi, Hadith Rastad, Ladan Hosseini. Association of Benign Breast Disorders with Hypothyroidism. İstanbul Med J. 2018; 19(3): 0-0

Sorumlu Yazar: Nooshin Shirzad, Iran


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