Three cases of Breast Cancer causing Paraneoplastic arthritis; case report and literature review

There is an interesting and complex relationship between rheumatic diseases and malignancy. Paraneoplastic arthritis is caused by the effects of many hormones and cytokines secreted from the underlying hidden tumor tissue. Here, there is no direct invasion or mechanical pressure of the tumor tissue. Especially in the early rheumatological disease period, the diagnosis should be reconsidered in cases unresponsive to conventional treatment. It should be kept in mind that there may be another underlying etiological factor in cases unresponsive to treatment. In this review, we discussed in detail three breast cancer cases who presented with early arthritis and were found to have breast cancer in the follow-up. When we look at the literature, serological marker, pathological diagnosis and imaging in breast cancer-associated paraneoplastic arthritis cases are not presented in detail. n our cases, serological markers, pathological diagnosis and breast MRI images are presented in detail.