A Familial Mediterranean Fever patient with mesangial proliferative glomerulonephritis: a case report and literature reviewAyten Yazıcı1, Özlem Özdemir Işık1, Demir Kursat Yildiz2, Ayse Cefle11Kocaeli University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Kocaeli, Turkey 2Kocaeli University, School of Medicine, Department of Pathology, Kocaeli, Turkey
Amyloidosis is the most important kidney complication determining the prognosis of Familial Mediterranean Fever (FMF) and presents with proteinuria at a nephrotic level. Other than amyloidosis, several other different renal involvements have been reported in FMF. The case is here presented of a patient determined with mesangial proliferative glomerulonephritis (MsPGN) in the kidney biopsy taken because of proteinuria and, a good response with colchicine and azathioprine treatment is presented. In this study, evaluations were made of cases with glomerulopathy other than amyloidosis in literature. The data of a total of 31 cases were analyzed and it was seen that MsPGN was reported in almost half of these. Hematuria was also reported in some of these patients, the majority of whom had nephrotic range proteinuria. Although colchicine treatment was sufficient in most cases, some were administered corticosteroid and azathioprine treatment. In conclusion, in FMF patients determined with proteinuria and/or hematuria, it should be kept in mind that there may be not only amyloidosis but also renal involvements other than amyloidosis, and the differential diagnosis should be made with kidney biopsy. Although colchicine treatment seems to be effective in renal involvements other than amyloidosis, immunosuppressive treatments may be necessary in some cases. Keywords: familial Mediterranean fever, amiloidosis, glomerulonephritis, colchicine
Ayten Yazıcı, Özlem Özdemir Işık, Demir Kursat Yildiz, Ayse Cefle. A Familial Mediterranean Fever patient with mesangial proliferative glomerulonephritis: a case report and literature review. Rheumatol Q. 2023; 1(2): 0-0
Corresponding Author: Ayten Yazıcı, Türkiye |
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